BACKGROUND: Coronary angiography is the standard method for guiding percutaneous coronary intervention and often underestimates or overestimates severity of the lesions. Fractional flow reserve and intravascular ultrasonography provide physiologic and anatomical intracoronary pressure measurements that can be used for stent placement.
OBJECTIVE: This study aims to determine the accuracy of combination Fractional Flow Reserve and Intravascular ultrasound versus the standard coronary angiogram guided percutaneous coronary intervention in the clinical outcome of patients with intermediate coronary artery stenosis
METHODS: Retrospective, cohort study involving patients with an intermediate coronary artery lesions, defined as 50-70% stenosis by angiography. In total, 72 patients underwent angiography-guided PCI and PCI guided by FFR with IVUS in Cardinal Santos Medical Center between January 2010 and June 2014. Patients were followed after hospital discharge.
RESULTS: FFR with IVUS was used in 36 patients (2.1%). The major adverse cardiovascular events occurred in 2 patients (6%) in the FFR with IVUS group and in 3 patients (8%) in the angiography group (P = 1.000). Angina occurred in 5 patients (14%) in the FFR with IVUS group and in 12 patients (33%) in the angiography group (P = 0.094).
CONCLUSION: CONFIGURE study showed no long term improvement in the clinical outcomes from the combination use of FFR and IVUS -guided PCI as compared with the standard angiography-guided PCI.